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After completing this course, the reader will be able to:

• Describe the site-specific dysregulation of some miRNAs and explain their potential as non-invasive biomarkers for diagnosis, prognostication, or markers of treatment response.
• Cite the characteristics reflected by circulating miR-195 and explain how elevated levels could be used as a breast tumor marker.

CME This article is available for continuing medical education credit at CME.TheOncologist.com

The potential of microRNAs (miRNAs) as novel tumor markers has been the focus of recent scrutiny because of their tissue specificity, stability, and association with clinicopathological parameters. Data have emerged documenting altered systemic miRNA expression across a spectrum of cancers; however, it remains uncertain as to whether circulating miRNAs are tumor specific. Our …