作者
John P Christianson, Evan D Paul, Myra Irani, Brittany M Thompson, Kenneth H Kubala, Raz Yirmiya, Linda R Watkins, Steven F Maier
发表日期
2008/11/3
期刊
Behavioural brain research
卷号
193
期号
1
页码范围
87-93
出版商
Elsevier
简介
Research investigating how control over stressors affects behavior often utilizes freezing and shuttle escape learning as the behavioral endpoints. These endpoints have been argued to reflect anxious or depressed states, but these descriptions are problematic. The present study sought to determine the impact of stressor controllability and the dorsal raphé nucleus (DRN) on sucrose preference and juvenile social exploration, putative measures of anhedonia and anxiety that are commonly used in studies of stress per se. In Experiment 1 rats were exposed to escapable stress (ES) or yoked-inescapable stress (IS) tailshocks. In Experiment 2 ES or IS was given 7 days before all rats received IS. In Experiment 3 the DRN was inactivated during IS by microinjection of 8-OH-DPAT. Sucrose preference and social exploration were tested for several days after stress. A fourth experiment confirmed that juvenile social …
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