作者
Jae-Min Kim, Robert Stewart, Kyung-Yeol Bae, Sung-Wan Kim, Hee-Ju Kang, Il-Seon Shin, Joon-Tae Kim, Man-Seok Park, Myung-Kyu Kim, Sung-Woo Park, Young-Hoon Kim, Jong-Keun Kim, Ki-Hyun Cho, Jin-Sang Yoon
发表日期
2012/2/1
期刊
Journal of affective disorders
卷号
136
期号
3
页码范围
833-840
出版商
Elsevier
简介
BACKGROUND
Polymorphisms of serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD). Serotonin 2a receptor (5-HTR2a) genes have not been yet investigated in PSD. This study aimed to investigate whether the 5-HTT, 5-HTR2a, and BDNF genes are associated with PSD independently and/or interactively in a Korean sample with high prevalence of risk alleles.
METHODS
In 276 stroke cases, depression was diagnosed using DSM-IV at 2weeks after stroke, further classified to major PSD (N=29), all (major plus minor) PSD (N=77), and control (N=199) groups. Associations between PSD and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, 5-HTR2a 102T/C, and BDNF val66met genotypes were estimated using logistic regression models, and gene–gene interactions were investigated using the generalized multifactor …
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JM Kim, R Stewart, KY Bae, SW Kim, HJ Kang, IS Shin… - Journal of affective disorders, 2012