作者
Dolly O Baliunas, Benjamin J Taylor, Hyacinth Irving, Michael Roerecke, Jayadeep Patra, Satya Mohapatra, Jürgen Rehm
发表日期
2009/11/1
来源
Diabetes care
卷号
32
期号
11
页码范围
2123-2132
出版商
American Diabetes Association
简介
OBJECTIVE
To clarify the dose-response relationship between alcohol consumption and type 2 diabetes.
RESEARCH DESIGN AND METHODS
A systematic computer-assisted and hand search was conducted to identify relevant articles with longitudinal design and quantitative measurement of alcohol consumption. Adjustment was made for the sick-quitter effect. We used fractional polynomials in a meta-regression to determine the dose-response relationships by sex and end point using lifetime abstainers as the reference group.
RESULTS
The search revealed 20 cohort studies that met our inclusion criteria. A U-shaped relationship was found for both sexes. Compared with lifetime abstainers, the relative risk (RR) for type 2 diabetes among men was most protective when consuming 22 g/day alcohol (RR 0.87 [95% CI 0.76–1.00]) and became deleterious at …
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