作者
Benjamin Taylor, Hyacinth M Irving, Dolly Baliunas, Michael Roerecke, Jayadeep Patra, Satya Mohapatra, Jurgen Rehm
发表日期
2009/12
来源
Addiction
卷号
104
期号
12
页码范围
1981-1990
出版商
Blackwell Publishing Ltd
简介
Aims  To analyze the dose–response relationship between average daily alcohol consumption and the risk of hypertension via systematic review and meta‐analysis.
Design  A computer‐assisted search was completed for 10 databases, followed by hand searches of relevant articles. Only studies with longitudinal design, quantitative measurement of alcohol consumption and biological measurement of outcome were included. Dose–response relationships were assessed by determining the best‐fitting model via first‐ and second‐degree fractional polynomials. Various tests for heterogeneity and publication bias were conducted.
Findings  A total of 12 cohort studies were identified from the literature from the United States, Japan and Korea. A linear dose–response relationship with a relative risk of 1.57 at 50 g pure alcohol per day and 2.47 at 100 g per day was seen for men. Among women, the meta‐analysis …
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