作者
Jeffrey A Haspel, Ron Anafi, Marishka K Brown, Nicolas Cermakian, Christopher Depner, Paula Desplats, Andrew E Gelman, Monika Haack, Sanja Jelic, Brian S Kim, Aaron D Laposky, Yvonne C Lee, Emmanuel Mongodin, Aric A Prather, Brian J Prendergast, Colin Reardon, Albert C Shaw, Shaon Sengupta, Éva Szentirmai, Mahesh Thakkar, Wendy E Walker, Laura A Solt
发表日期
2020/1/1
来源
JCI insight
卷号
5
期号
1
出版商
American Society for Clinical Investigation
简介
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation—are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop,“Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.
学术搜索中的文章
JA Haspel, R Anafi, MK Brown, N Cermakian… - JCI insight, 2020