作者
Nirali Rathwa, Roma Patel, Sayantani Pramanik Palit, Nishant Parmar, Sneha Rana, Mohammad Ismail Ansari, AV Ramachandran, Rasheedunnisa Begum
发表日期
2020/10/30
来源
Nutrition, Metabolism and Cardiovascular Diseases
卷号
30
期号
11
页码范围
1870-1881
出版商
Elsevier
简介
Aims
Diabetes mellitus (DM) is a disorder of heterogeneous etiology marked by persistent hyperglycemia. Exogenous insulin is the only treatment for type 1 diabetes (T1D). Islet transplantation is a potential long cure for T1D but is disapproved due to the possibility of immune rejection in the later stage. The approaches used for treating type 2 diabetes (T2D) include diet restrictions, weight management and pharmacological interventions. These procedures have not been able to boost the quality of life for diabetic patients owing to the complexity of the disorder.
Data synthesis
Hence, research has embarked on permanent ways of managing, or even curing the disease. One of the possible approaches to restore the pancreas with new glucose-responsive β-cells is by their regeneration. Regeneration of β-cells include islet neogenesis, dedifferentiation, and trans-differentiation of the already differentiated cells …
引用总数
20212022202320245523
学术搜索中的文章
N Rathwa, R Patel, SP Palit, N Parmar, S Rana… - Nutrition, Metabolism and Cardiovascular Diseases, 2020