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In non-clinical studies the efficacy of a full-strength and a 1/5th dose of OXB-102 has been compared to the efficacy of full-strength ProSavin® in the ‘gold standard’MPTP NHP model of PD; a vector that does not express any genes was used as a negative control. The longitudinal follow-up consisted of recording clinical rating scores and video-based quantification of locomotor activity before and after vector administration. The full-strength and the 1/5th dose of OXB-102 were as efficacious as the full-strength dose of ProSavin®, whereas the control-treated macaques maintained a significant PD phenotype, indicating improved dopamine production from OXB-102. Positron emission tomography (PET) was also carried out at baseline and at 3 and 6 months following vector administration using 18F-FMT, a presynaptic biomarker that acts as a substrate of AADC. There was a significant increase in the FMT signal in …