作者
Pedro A Villablanca, Verghese Mathew, Vinod H Thourani, Josep Rodés-Cabau, Sripal Bangalore, Mohammed Makkiya, Peter Vlismas, David F Briceno, David P Slovut, Cynthia C Taub, Patrick M McCarthy, John G Augoustides, Harish Ramakrishna
发表日期
2016/12/15
期刊
International journal of cardiology
卷号
225
页码范围
234-243
出版商
Elsevier
简介
Background
Transcatheter aortic valve replacement (TAVR) has emerged as an alternative to surgical aortic-valve replacement (SAVR) for patients with severe symptomatic aortic stenosis (AS) who are at high operative risk. We sought to determine the long-term (≥ 1 year follow-up) safety and efficacy TAVR compared with SAVR in patients with severe AS.
Methods
A comprehensive search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, conference proceedings, and relevant Web sites from inception through 10 April 2016.
Results
Fifty studies enrolling 44,247 patients met the inclusion criteria. The mean duration follow-up was 21.4 months. No difference was found in long-term all-cause mortality (risk ratios (RR), 1.06; 95% confidence interval (CI) 0.91–1.22). There was a significant difference favoring TAVR in the incidence of stroke (RR, 0.82; 95% CI 0.71–0.94), atrial fibrillation (RR, 0.43; 95 …
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PA Villablanca, V Mathew, VH Thourani… - International journal of cardiology, 2016