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Telerehabilitation (TR) seems to be an encouraging solution for the delivery of cognitive treatments in patients with neurological disorders. This study was aimed to analyze and synthesize the evidence on the efficacy of cognitive TR interventions in patients with neurological diseases, compared with conventional face-to-face rehabilitation. From a total of 4485 records, 9 studies met the inclusion criteria for qualitative analysis. At the end of the process, 7 studies remained for quantitative analysis. By comparing TR with face-to-face treatments for cognitive impairments, we assessed improvements in global cognitive domain (Mini Mental State Exam) (MD = −0.86; 95% CI −2.43, 0.72, I² = 0%), in learning and memory domains (SMD = 0.26, 95% CI −0.22, 0.74, I² = 24%), in verbal fluency (SMD = 0.08, 95% CI −0.47, 0.62, I² = 0%), and in executive functions (i.e., problem-solving, central processing speed and …