作者
Zakuan Z Deris, Heidi H Yu, Kathryn Davis, Rachel L Soon, Jovan Jacob, Caron K Ku, Anima Poudyal, Phillip J Bergen, Brian T Tsuji, Jurgen B Bulitta, Alan Forrest, David L Paterson, Tony Velkov, Jian Li, Roger L Nation
发表日期
2012/10
期刊
Antimicrobial agents and chemotherapy
卷号
56
期号
10
页码范围
5103-5112
出版商
American Society for Microbiology
简介
Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharmacodynamic model was employed over a 72-h period with two inocula (∼106 and ∼108 CFU/ml); a colistin-heteroresistant reference strain (ATCC 13883) and three clinical isolates (colistin-susceptible FADDI-KP032 [doripenem resistant], colistin-heteroresistant FADDI-KP033, and colistin-resistant FADDI-KP035) were included. Four combinations utilizing clinically achievable concentrations were investigated. Microbiological responses were examined by determining log changes and population analysis profiles (for emergence of colistin resistance) over 72 h. Against colistin-susceptible and …
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ZZ Deris, HH Yu, K Davis, RL Soon, J Jacob, CK Ku… - Antimicrobial agents and chemotherapy, 2012