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Curcumin is recognized as a potential chemotherapeutic agent against a variety of tumors. However, the clinical application of curcumin is hindered due to its poor water solubility and fast degradation. The objective of this study was to investigate amphiphilic block copolymer micelles of poly(ethylene oxide)‐b‐poly(ϵ‐caprolactone) (PEO‐PCL) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. Curcumin‐loaded PEO‐PCL micelles were prepared by a cosolvent evaporation technique. PEO‐PCL micelles were able to solubilize curcumin effectively, protect the encapsulated curcumin from hydrolytical degradation in physiological matrix, and control the release of curcumin over a few days. The characteristics of resultant micelles were found to depend on the polymerization degrees of ϵ‐caprolactone. Among different PEO‐PCL micelles, PEO₅₀₀₀‐PCL₂₄₅₀₀ was the most efficient in …