作者
Hill F Ip, Camiel M Van der Laan, Eva ML Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A Wang, Gretchen Saunders, Ville Karhunen, Anke R Hammerschlag, Daniel E Adkins, Richard Border, Roseann E Peterson, Joseph A Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S Ahluwalia, Felix R Day, Jouke-Jan Hottenga, Andrea G Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G Scott, Anna Vinkhuyzen, Andrey A Shabalin, Robin Corley, Luke M Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E Davies, Erik A Ehli, Fiona A Hagenbeek, Eveline De Zeeuw, Toos CEM Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C Verhulst, Najaf Amin, Alyce M Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J Rose, André G Uitterlinden, Andrew C Heath, Pamela Madden, Jan Haavik, Jennifer R Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K Henders, Abdullah Mamun, Jackob M Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L Wall, Judy L Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T Raitakari, John RB Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L John Horwood, Martin Kennedy, Richie Poulton, Lindon J Eaves, Hermine H Maes, John Hewitt, William E Copeland, Elizabeth J Costello, Gail M Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E Moffitt, Andrew Whitehouse, Craig E Pennell, Kelly L Klump, S Alexandra Burt, Danielle M Dick, Ted Reichborn-Kjennerud, Nicholas G Martin, Sarah E Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A Hartman, Albertine J Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G Nivard, Dorret I Boomsma
发表日期
2021/7/30
期刊
Translational psychiatry
卷号
11
期号
1
页码范围
413
出版商
Nature Publishing Group UK
简介
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E–06), PCDH7 (P = 2.0E–06), and IPO13 (P = 2.5E–06). All three genes have previously been associated with educational traits. Polygenic scores based on our …
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HF Ip, CM Van der Laan, EML Krapohl, I Brikell… - Translational psychiatry, 2021