作者
Jennifer Nichols, Austin Smith
发表日期
2009/6/5
来源
Cell stem cell
卷号
4
期号
6
页码范围
487-492
出版商
Elsevier
简介
After maternal predetermination gives way to zygotic regulation, a ground state is established within the mammalian embryo. This tabula rasa for embryogenesis is present only transiently in the preimplantation epiblast. Here, we consider how unrestricted cells are first generated and then prepared for lineage commitment. We propose that two phases of pluripotency can be defined: naive and primed. This distinction extends to pluripotent stem cells derived from embryos or by molecular reprogramming ex vivo.
引用总数
学术搜索中的文章
J Nichols, A Smith - Cell stem cell, 2009