作者
Myrto Stylianou, Nicholas Murphy, Luis R Peraza, Sara Graziadio, Ruth Cromarty, Alison Killen, John T O'Brien, Alan J Thomas, Fiona EN LeBeau, John-Paul Taylor
发表日期
2018/6/1
期刊
Clinical Neurophysiology
卷号
129
期号
6
页码范围
1209-1220
出版商
Elsevier
简介
Objective
We investigated for quantitative EEG (QEEG) differences between Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctuations (CFs) in DLB.
Methods
We analysed eyes-closed, resting state EEGs from 18 AD, 17 DLB and 17 PDD patients with mild dementia, and 21 age-matched controls. Measures included spectral power, dominant frequency (DF), frequency prevalence (FP), and temporal DF variability (DFV), within defined EEG frequency bands and cortical regions.
Results
DLB and PDD patients showed a leftward shift in the power spectrum and DF. AD patients showed greater DFV compared to the other groups. In DLB patients only, greater DFV and EEG slowing were correlated with CFs, measured by the clinician assessment of fluctuations (CAF) scale. The diagnostic accuracy of …
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M Stylianou, N Murphy, LR Peraza, S Graziadio… - Clinical Neurophysiology, 2018