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SSATA b st ra ct s on endoscopy, and magnetic resonance tumor regression grade (mrTRG) 1-2 were predictors of CR in the univariate analysis. In the multivariate analysis, absence of EMVI andcomplete/near complete response in endoscopy were associated with CR. Compared to MRI, endoscopy wasmore sensitive in predicting CR (76.9% vs. 65.9%). Endoscopy, when combined with MRI, was more specific inpredicting CR compared to endoscopy alone (82.6% vs. 72.5%). During a median follow-up of 18.9 months, recurrence was observed in 24 (20%) patients. Disease-free and overall survival rates were 75% and 77.2% following 2 years of completion of TNT, respectively. Conclusions: In this cohort of locally advanced rectal cancer patients, TNT achieved 36.9% CR. Absence of EMVI was the only independent predictor of CR at the time of diagnosis. Following TNT, endoscopy is a better predictor of CR than …