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Emulgel is one of the recent technologies in NDDS used for dual control release of emulsion and gel for topical use. Gel formulations generally provide faster drug release compared with conventional ointments and creams. Spironolactone is a well-known therapeutic agent that is used mainly for its diuretic ability. Recently, it gained a lot of attention for treating alopecia due to its potent anti-androgenic properties. The aim and objective of the study is to formulate spironolactone loaded emulgel for topical application. Emulgel of spironolactone, consist of carbopol-947 or carbopol-974 or HPMCk15 or xanthan gum as a gelling agents for gel formulation and tween 20, span 20, light, PEG-400, light liquid paraffin for emulsion formulation. Emulgel was formulated by emulsion incorporated in gel. Spironolactone loaded emulgel was formulated by using o/w emulsion because of lower solubility in water. Mentha oil was used as a penetration enhancer in emulgel formulation. Optimization of spironolactone loaded emulgel by 32 full factorial design. Optimized formulation evaluated for was evaluated for physical examination, swelling index, skin irritation study, extrudability study, drug content determination, spreadability, globule size determination and in-vivo drug release, rheological study. Optimized formulation give drug release 78.47% and viscosity 1610 cps.