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Odontogenic tumours includes broad spectrum of lesions derived from specialized dental tissues. Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. They constitute abortive attempt at odontogenesis. Odontogenic tumors can be intraosseous or extraosseous with varying clinical and radiographic features. Odontogenic tumours are associated with molecular and genetic alterations. This review presents outline of molecular and genetic alterations associated with nature and growth of benign odontogenic tumours.