作者
Juan Chen, Xue-feng Hou, Gang Wang, Qing-xiang Zhong, Ying Liu, Hui-hui Qiu, Nan Yang, Jun-fei Gu, Chun-fei Wang, Li Zhang, Jie Song, Lu-qi Huang, Xiao-bin Jia, Ming-hua Zhang, Liang Feng
发表日期
2016/12/4
期刊
Journal of ethnopharmacology
卷号
193
页码范围
433-444
出版商
Elsevier
简介
Ethnopharmacological relevance
Multiple lines of evidences have suggested that endoplasmic reticulum (ER) stress-related inflammatory responses play a critical role in the pathogenesis of diabetic nephropathy (DN). Moutan Cortex (MC), the root bark of Paeonia suffruticosa Andr., is a well-known traditional Chinese medicine (TCM), which has been used clinically for treating inflammatory diseases in China. The findings from our previous research suggested that terpene glycoside (TG) component of MC possessed favorable anti-inflammatory properties in curing DN. However, the underlying mechanisms of MC-TG for treating DN are still unknown.
Aim of the study
To explore the role of ER stress-related inflammatory responses in the progression of DN, and to investigate the underlying protective mechanisms of MC-TG in kidney damage.
Materials and methods
DN rats and advanced glycation end-products (AGEs …
学术搜索中的文章
J Chen, X Hou, G Wang, Q Zhong, Y Liu, H Qiu, N Yang… - Journal of ethnopharmacology, 2016