作者
Dominik Modrzejewski, Frank Hartung, Thorben Sprink, Dörthe Krause, Christian Kohl, Ralf Wilhelm
发表日期
2019/12
期刊
Environmental Evidence
卷号
8
期号
1
页码范围
1-33
出版商
BioMed Central
简介
Background
Within the last decades, genome-editing techniques such as CRISPR/Cas, TALENs, Zinc-Finger Nucleases, Meganucleases, Oligonucleotide-Directed Mutagenesis and base editing have been developed enabling a precise modification of DNA sequences. Such techniques provide options for simple, time-saving and cost-effective applications compared to other breeding techniques and hence genome editing has already been promoted for a wide range of plant species. Although the application of genome-editing induces less unintended modifications (off-targets) in the genome compared to classical mutagenesis techniques, off-target effects are a prominent point of criticism as they are supposed to cause unintended effects, e.g. genomic instability or cell death. To address these aspects, this map aims to answer the following question: What is the available evidence for the range of applications of …
引用总数
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