作者
Belinda M Brown, Stephanie R Rainey-Smith, Victor L Villemagne, Michael Weinborn, Romola S Bucks, Hamid R Sohrabi, Simon M Laws, Kevin Taddei, S Lance Macaulay, David Ames, Christopher Fowler, Paul Maruff, Colin L Masters, Christopher C Rowe, Ralph N Martins, AIBL Research Group
发表日期
2016/5/1
期刊
Sleep
卷号
39
期号
5
页码范围
1063-1068
出版商
Oxford University Press
简介
Study Objectives
To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.
Methods
This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression …
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BM Brown, SR Rainey-Smith, VL Villemagne… - Sleep, 2016