作者
Raphael W Lihana, Samoel A Khamadi, Kizito Lubano, Raphael Lwembe, Michael K Kiptoo, Nancy Lagat, Joyceline G Kinyua, Fredrick A Okoth, Elijah M Songok, Ernest P Makokha, Hiroshi Ichimura
发表日期
2009/12/1
期刊
AIDS research and human retroviruses
卷号
25
期号
12
页码范围
1211-1217
出版商
Mary Ann Liebert, Inc.
简介
The treatment of HIV-1 infection with antiretroviral drugs has greatly improved the survival of those who are infected. However, HIV-1 diversity and drug resistance are major challenges in patient management, especially in resource-poor countries. To evaluate HIV-1 genetic diversity and drug resistance-associated mutations among drug-naive patients in Kenya prior to antiretroviral therapy (ART), a genetic analysis of HIV-1 pol-RT and env-gp41 was performed on samples collected from 53 (18 males and 35 females) consenting patients between April and June 2005. The average age, baseline CD4+ T cell counts, and viral loads were 38 (range, 24–62) years, 475 (range, 203–799) cells/mm3, and 4.7 (range, 3.4–5.9) log10 copies/ml, respectively. Phylogenetic analysis revealed that 40 samples (75.5%) were concordant subtypes for the two genes and 13 (24.5%) were discordant, suggesting possible …
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RW Lihana, SA Khamadi, K Lubano, R Lwembe… - AIDS research and human retroviruses, 2009