作者
Trevor A Crowell, Brook Danboise, Ajay Parikh, Allahna Esber, Nicole Dear, Peter Coakley, Alex Kasembeli, Jonah Maswai, Samoel Khamadi, Emmanuel Bahemana, Michael Iroezindu, Francis Kiweewa, John Owuoth, Joanna Freeman, Linda L Jagodzinski, Jennifer A Malia, Leigh Ann Eller, Sodsai Tovanabutra, Sheila A Peel, Julie A Ake, Christina S Polyak, AFRICOS Study Group
发表日期
2021/10/1
期刊
Clinical Infectious Diseases
卷号
73
期号
7
页码范围
e2311-e2322
出版商
Oxford University Press
简介
Background
Emerging HIV drug resistance (HIVDR) could jeopardize the success of standardized HIV management protocols in resource-limited settings. We characterized HIVDR among antiretroviral therapy (ART)-naive and experienced participants in the African Cohort Study (AFRICOS).
Methods
From January 2013 to April 2019, adults with HIV-1 RNA >1000 copies/mL underwent ART history review and HIVDR testing upon enrollment at 12 clinics in Uganda, Kenya, Tanzania, and Nigeria. We calculated resistance scores for specific drugs and tallied major mutations to non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleoside reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) using Stanford HIVDB 8.8 and SmartGene IDNS software. For ART-naive participants, World Health Organization surveillance drug resistance mutations (SDRMs …
学术搜索中的文章
TA Crowell, B Danboise, A Parikh, A Esber, N Dear… - Clinical Infectious Diseases, 2021