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A very recent study by Zhang et al. published in Nature demonstrates that gasdermin E (GSDME, also known as DFNA5) is a tumour suppressor by activating caspaseindependent pyroptosis to enhance anti-tumour immunity. 1 In the meantime, a study by Wang et al. published in Nature also demonstrates the anti-tumour effect caused by gasdermin A3 (GSDMA3) to induce pyroptosis requires both cytotoxic T cells and CD4+ T helper cells. 2 The authors intriguingly showed that pyroptosis-induced inflammation triggers robust anti-tumour immunity, thus gasdermin is a promising novel therapeutic target for tumour treatment (Fig. 1).

Pyroptosis is one kind of programmed necrosis mediated by the gasdermin family. 3 The gasdermin family includes GSDMD, GSDMA, GSDMB, GSDMC, GSDME, and DFNB59. GSDMD is identified as the pyroptotic substrate of caspase-1/4/5/11 and multiple gasdermin-N domains can bind …