作者
Thomas Bein, Steffen Weber-Carstens, Anton Goldmann, Thomas Müller, Thomas Staudinger, Jörg Brederlau, Ralf Muellenbach, Rolf Dembinski, Bernhard M Graf, Marlene Wewalka, Alois Philipp, Klaus-Dieter Wernecke, Matthias Lubnow, Arthur S Slutsky
发表日期
2013/5
期刊
Intensive care medicine
卷号
39
页码范围
847-856
出版商
Springer-Verlag
简介
Background
Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V T) strategy (V T ≈ 3 ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS.
Methods
Seventy-nine patients were enrolled after a ‘stabilization period’ (24 h with optimized therapy and high PEEP). They were randomly assigned to receive a low V T ventilation (≈3 ml/kg) combined with extracorporeal CO2 elimination, or to a ARDSNet strategy (≈6 ml/kg) without the extracorporeal device. The primary outcome was the 28-days and 60-days ventilator-free days (VFD). Secondary outcome parameters were respiratory …
学术搜索中的文章
T Bein, S Weber-Carstens, A Goldmann, T Müller… - Intensive care medicine, 2013