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Cancers can be solid tumors or hematologic and different approaches are needed for each kind of cancer. Solid tumors show a heterogeneous and dynamic biology that keeps changing with time. Breast cancer is a heterogeneous and solid tumor. Genetic factors can be responsible about the occurance of 5%-10% of breast cancer cases [1, 2]. Many risk factors can affect the development of breast cancer disease such as status of lymph node, size of the tumor, age of the patient, histological grade and type or status of human epidermal growth factor receptor 2 (HER-2), estrogen receptor (ER) and progesterone receptor [3]. Early diagnosis can play an important role in decreasing the progression of disease and reducing the rate of death [4]. Traditional therapy of breast cancer which includes radiothaerapy, surgical resection combining with chemotherapy can affect both cancer and non-cancer cells [5–7]. In addition, about 95% of anticancer thaerapies have poor biopharmaceutical and pharmacokinetics properties such as very short circulation half-life or poor water soluble drugs. Innovative technologies such as nanotechnology can apply to improve the diagnosis, imaging and efficacy of breast cancer treatment [8–10]. Nanotechnology concerns any devices whose dimensions are within the range of 1–1, 00 nm [11–14]. Nanotechnology can include nanomedicines, nanomanufacturing, nanocarriers, nanomaterials, nanoscale devices and societal studies of nanotechnology benefits and risks [8]. Many nanotechnology products are approved by Food and Drug Administration (FDA) for clinical use, and more are in clinical trials [12]. Polymers …