作者
Renata Batista-Brito, Elsa Rossignol, Jens Hjerling-Leffler, Myrto Denaxa, Michael Wegner, Véronique Lefebvre, Vassilis Pachnis, Gord Fishell
发表日期
2009/8/27
期刊
Neuron
卷号
63
期号
4
页码范围
466-481
出版商
Elsevier
简介
We describe the role of Sox6 in cortical interneuron development, from a cellular to a behavioral level. We identify Sox6 as a protein expressed continuously within MGE-derived cortical interneurons from postmitotic progenitor stages into adulthood. Both its expression pattern and null phenotype suggests that Sox6 gene function is closely linked to that of Lhx6. In both Lhx6 and Sox6 null animals, the expression of PV and SST and the position of both basket and Martinotti neurons are abnormal. We find that Sox6 functions downstream of Lhx6. Electrophysiological analysis of Sox6 mutant cortical interneurons revealed that basket cells, even when mispositioned, retain characteristic but immature fast-spiking physiological features. Our data suggest that Sox6 is not required for the specification of MGE-derived cortical interneurons. It is, however, necessary for their normal positioning and maturation. As a …
引用总数
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