作者
Rumbidzai J Magee, Mark K Santillan, Alexandria M Betz, Lyndsey E DuBose, Allison O'Deen, Seth W Holwerda, Amy K Stroud, Debra S Brandt, Nicholas Jensen, Rachel E Luehrs, Donna A Santillan, Justin L Grobe, Curt D Sigmund, Gary L Pierce
发表日期
2018/4
期刊
The FASEB Journal
卷号
32
页码范围
715.13-715.13
出版商
The Federation of American Societies for Experimental Biology
简介
Preeclampsia is a pregnancy disorder that effects ~5–8% of all pregnancies and is characterized by de novo hypertension, proteinuria and multiple organ dysfunction in late gestation. Higher levels of leisure time physical activity (LTPA) are associated with lower risk of preterm delivery and preeclampsia in pregnancy. Women who develop preeclampsia demonstrate increased central artery stiffness and vascular endothelial dysfunction in early/mid gestation before clinical signs/symptoms of preeclampsia manifest. Therefore, we hypothesized that 1) higher total LTPA would be associated with lower arterial stiffness and higher vascular endothelial function during each trimester in pregnant women, and 2) compared with normal pregnancy, women who develop preeclampsia would demonstrate lower LTPA, higher arterial stiffness and lower endothelial function in early/mid gestation before signs of preeclampsia …
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