查看文章

Obesity is associated with increased sympathetic outflow and hypertension. However, it remains unclear whether the systemic pressor response to spontaneous bursts of sympathetic nerve activity (i.e., sympathetic transduction) is augmented in obesity. Therefore, we tested the hypothesis that transduction of muscle sympathetic nerve activity (MSNA) to arterial blood pressure (BP) is significantly higher in obese vs. lean adults. Also, because obesity alters regulation of BP over the 24‐hour period, we further examined the extent to which sympathetic transduction is associated with ambulatory 24‐hour BP variability (standard deviation). MSNA (microneurography) and arterial BP (finger cuff) were measured continuously for 10 min under resting conditions in 20 young/middle‐age obese participants and 20 age‐ and sex‐matched lean controls. Signal averaging was used to characterize beat‐by‐beat changes in …