作者
Ewa Bulzacka, Laurent Boyer, Franck Schürhoff, Ophélia Godin, Fabrice Berna, Lore Brunel, Méja Andrianarisoa, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chéreau-Boudet, Gabrielle Chesnoy-Servanin, Jean-Marie Danion, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Tifenn Le Gloahec, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Romain Rey, Raphaëlle Richieri, Christine Passerieux, Paul Roux, Hanan Yazbek, Marion Leboyer, Guillaume Fond, FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) Group
发表日期
2016/9/1
期刊
Schizophrenia bulletin
卷号
42
期号
5
页码范围
1290-1302
出版商
Oxford University Press
简介
Objectives
Inflammation, measured by abnormal blood C-reactive protein (CRP) level, has been described in schizophrenia (SZ), being inconsistently related to impaired cognitive functions. The aim of the present study is to investigate cognitive impairment associated with abnormal CRP levels in a large multi-centric sample of community-dwelling SZ patients, using a comprehensive neuropsychological battery.
Method
Three hundred sixty-nine community-dwelling stable SZ subjects (76.2% men, mean age 32.7 y) were included and tested with a comprehensive battery of neuropsychological tests. Abnormal CRP level was defined as >3mg/L.
Results
Multiple factor analysis revealed that abnormal CRP levels, found in 104 patients (28.2%), were associated with impaired General Intellectual Ability and Abstract Reasoning (aOR = 0.56, 95% CI 0.35 …
学术搜索中的文章
E Bulzacka, L Boyer, F Schürhoff, O Godin, F Berna… - Schizophrenia bulletin, 2016