作者
Ahmed O Abdelaty, Engy K Tharwat, Alaa I Abdelrahman, Ayatallah Elgohary, Hebatallah Elsaeed, Amena S El-Feky, Yasmina M Ebrahim, Abdelaziz Habib, Hasnaa Abd El Latif, Yasser A Khadrawy, Heba S Aboul Ezz, Neveen A Noor, Heba M Fahmy, Faten F Mohammed, Nasr M Radwan, Nawal A Ahmed
发表日期
2024/4/1
期刊
Journal of Psychiatric Research
卷号
172
页码范围
171-180
出版商
Pergamon
简介
Rationale
Depression is the most prevalent psychiatric disorder worldwide. Although numerous antidepressant treatments are available, there is a serious clinical concern due to their severe side effects and the fact that some depressed patients are resistant to them. Lithium is the drug of choice for bipolar depression and has been used as adjunct therapy with other groups of antidepressants.
Objectives
The present study aims to investigate the effect of lithium augmentation with cerebrolysin on the neurochemical, behavioral and histopathological alterations induced in the reserpine model of depression.
Methods
The animals were divided into control and reserpine-induced model of depression. The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Results
Treatment …
学术搜索中的文章
AO Abdelaty, EK Tharwat, AI Abdelrahman, A Elgohary… - Journal of Psychiatric Research, 2024