作者
Tim J Sargeant, Darren J Day, John H Miller, Ryan WJ Steel
发表日期
2008/9
期刊
European Journal of Neuroscience
卷号
28
期号
6
页码范围
1060-1067
出版商
Blackwell Publishing Ltd
简介
The antiproliferative effects of opiate exposure on neurogenesis in vitro have been well documented, but the effects of opiates on brain development in vivo are less well understood. We have recently shown that mu opioid receptors are expressed on radial glia of the lateral ventricle, the neuronal and glial progenitor cells of the developing cortex. In the present study we show that in vivo morphine treatment of the E15.5 mouse increases the length of the G2/M phase of the radial glial cell cycle in the dorsal telencephalon, as well as slows interkinetic nuclear migration of radial glial nuclei from the basal ventricular zone to the apical surface. A prolonged G2/M phase was also observed in basal progenitor cells. Although morphine exposure altered the duration of the cell cycle for progenitor cells in the embryonic telencephalon, it did not affect whether the progenitors remained proliferative and re‐entered the S phase …
学术搜索中的文章
TJ Sargeant, DJ Day, JH Miller, RWJ Steel - European Journal of Neuroscience, 2008