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Seventeen years have passed since Phil Bourne inaugurated the Ten Simple Rule (TSR) collection in PLOS Computational Biology (PLOS CB) with a paper entitled “Ten Simple Rules for Getting Published”[1]. At that time, the change in how we communicate sciences had already begun [2]: social media was blooming, the information deluge was ongoing, and the fear of missing information was anchored in each of us. The Ten Simple Rules collection filled a space in scientific publications where researchers eager to share their experiences, wisdom, and doubts could quickly do it using a colloquial narrative. The topics covered were broad themes in scientific practice, such as soft skills and career development, captured in a concise and quick-to-read format, something between a blog post and a scientific article. This type of article attracted much interest from readers. In 2018, the collection reached the milestone of 1,000 Rules [3], and today this figure is above 250 papers (2,500 Rules!)[4]. With the increase of technical and scientific topics, in 2013, PLOS Computational Biology tried a new experience with a similar format—we introduced “Quick Tips”(QT) articles—with the attempt to make a clear distinction between the more specific and focused scientific activities and skills presented with resources, databases, and other tools in Quick Tips versus the broader themes presented in a Ten Simple Rules article.“Ten Simple Rules for Writing a PLOS Ten Simple Rules Article”[5] explains the Ten Simple Rules concept, format, and reasoning very well and is still relevant today. Inspired by that article, we wrote this Ten Simple Rules paper intending to …