作者
MB Urowitz, DD Gladman, D Ibanez, PR Fortin, SC Bae, C Gordon, A Clarke, S Bernatsky, JG Hanly, D Isenberg, A Rahman, J Sanchez‐Guerrero, DJ Wallace, E Ginzler, GS Alarcón, JT Merrill, IN Bruce, Gunnar Sturfelt, Ola Nived, K Steinsson, M Khamashta, M Petri, S Manzi, R Ramsey‐Goldman, MA Dooley, RF Van Vollenhoven, M Ramos, T Stoll, A Zoma, K Kalunian, C Aranow
发表日期
2012/1
期刊
Arthritis care & research
卷号
64
期号
1
页码范围
132-137
出版商
John Wiley & Sons, Inc.
简介
Objective
We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort.
Methods
The Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI‐2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti‐DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated‐measures general linear models were used to evaluate …
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MB Urowitz, DD Gladman, D Ibanez, PR Fortin, SC Bae… - Arthritis care & research, 2012