作者
A Rodriguez Guardado, A Blanco, V Asensi, F Pérez, JC Rial, V Pintado, E Bustillo, M Lantero, E Tenza, M Alvarez, JA Maradona, JA Cartón
发表日期
2008/4/1
期刊
Journal of Antimicrobial Chemotherapy
卷号
61
期号
4
页码范围
908-913
出版商
Oxford University Press
简介
Background
The treatment of multidrug-resistant Acinetobacter baumannii meningitis is a serious therapeutic problem due to the limited penetration of antibiotics into the CSF. We describe the clinical features and the outcome of a group of patients with nosocomial neurosurgical meningitis treated with different therapeutic options.
Methods
All patients with nosocomial post-surgical meningitis due to A. baumannii diagnosed between 1990 and 2004 were retrospectively reviewed.
Results
During the period of study, 51 cases of this nosocomial infection were identified. Twenty-seven patients were treated with intravenous (iv) monotherapy: carbapenems (21 cases), ampicillin/sulbactam (4 cases) and other antibiotics (2 cases). Four patients were treated with iv combination therapy. Nineteen patients were treated with iv and intrathecal regimens: colistin by both …
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