作者
Maciej Tomaszewski, Christobelle White, Prashanth Patel, Nicholas Masca, Ravi Damani, Joanne Hepworth, Nilesh J Samani, Pankaj Gupta, Webster Madira, Adrian Stanley, Bryan Williams
发表日期
2014/6/1
期刊
Heart
卷号
100
期号
11
页码范围
855-861
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objectives
Non-adherence to therapy is an important cause of suboptimal blood pressure control but few practical tools exist to accurately and routinely detect it. We used a simple urine-based assay to evaluate the prevalence of antihypertensive treatment non-adherence and its impact on blood pressure in a specialist hypertension centre.
Methods
208 hypertensive patients (125 new referrals, 66 follow-up patients with inadequate blood pressure control and 17 renal denervation referrals) underwent assessment of antihypertensive drug intake using high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis at the time of clinical appointment. A total of 40 most commonly prescribed antihypertensive medications (or their metabolites) were screened for in spot urine samples.
Results
Overall, 25% of patients were totally or partially non-adherent to antihypertensive treatment …
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M Tomaszewski, C White, P Patel, N Masca, R Damani… - Heart, 2014