作者
Benjamin A Flusberg, Axel Nimmerjahn, Eric D Cocker, Eran A Mukamel, Robert PJ Barretto, Tony H Ko, Laurie D Burns, Juergen C Jung, Mark J Schnitzer
发表日期
2008/11
期刊
Nature methods
卷号
5
期号
11
页码范围
935-938
出版商
Nature Publishing Group US
简介
A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge. We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca2+ dynamics.
引用总数
学术搜索中的文章
BA Flusberg, A Nimmerjahn, ED Cocker, EA Mukamel… - Nature methods, 2008