作者
Wenchun Qu, Zhen Wang, Christine Hunt, Allison S Morrow, Meritxell Urtecho, Mustapha Amin, Sahrish Shah, Bashar Hasan, Rami Abd-Rabu, Zack Ashmore, Eva Kubrova, Larry J Prokop, Mohammad Hassan Murad
发表日期
2021/9/1
来源
Mayo Clinic Proceedings
卷号
96
期号
9
页码范围
2407-2417
出版商
Elsevier
简介
Objective
To evaluate the effectiveness and adverse events of autologous platelet-rich plasma (PRP) in individuals with lower-extremity diabetic ulcers, lower-extremity venous ulcers, and pressure ulcers.
Patients and Methods
We searched multiple databases from database inception to June 11, 2020, for randomized controlled trials and observational studies that compared PRP to any other wound care without PRP in adults with lower-extremity diabetic ulcers, lower-extremity venous ulcers, and pressure ulcers.
Results
We included 20 randomized controlled trials and five observational studies. Compared with management without PRP, PRP therapy significantly increased complete wound closure in lower-extremity diabetic ulcers (relative risk, 1.20; 95% CI, 1.09 to 1.32, moderate strength of evidence [SOE]), shortened time to complete wound closure, and reduced wound area and depth (low SOE). No significant …
学术搜索中的文章
W Qu, Z Wang, C Hunt, AS Morrow, M Urtecho, M Amin… - Mayo Clinic Proceedings, 2021