作者
Isao Matsui, Takayuki Hamano, Satoshi Mikami, Naohiko Fujii, Yoshitsugu Takabatake, Yasuyuki Nagasawa, Noritaka Kawada, Takahito Ito, Hiromi Rakugi, Enyu Imai, Yoshitaka Isaka
发表日期
2009/5/1
期刊
Kidney international
卷号
75
期号
9
页码范围
915-928
出版商
Elsevier
简介
The serum glycoprotein fetuin-A is an important inhibitor of extra-osseous calcification, but correlations between serum fetuin-A levels and the extent of vascular calcification are controversial. In this study, we used a rat model of adenine-induced renal failure with secondary hyperparathyroidism that exhibits all characteristic features of patients with chronic kidney disease. These rats had medial vascular calcification along with reduced levels of both serum and hepatic fetuin-A. Treatment with an inhibitor of ectopic calcification, alendronate, decreased bone turnover and eliminated completely the vascular calcification in this rat model, but there was no change in the levels of hepatic and serum fetuin-A. Centrifugation of the serum of untreated rats with renal failure gave a small precipitate composed of fetuin-A, calcium, magnesium, and phosphate; this complex, absent from normal rat serum, was not found in the …
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I Matsui, T Hamano, S Mikami, N Fujii, Y Takabatake… - Kidney international, 2009