作者
Sylvie Tordjman, George M Anderson, Annaelle Charrier, Cecile Oriol, Solenn Kermarrec, Roberto Canitano, Michel Botbol, Nathalie Coulon, Corinne Antoine, Sylvie Brailly-Tabard, David Cohen, Hazar Haidar, Severine Trabado, Michèle Carlier, Guillaume Bronsard, Laurent Mottron
发表日期
2018/3/13
期刊
The Journal of Clinical Psychiatry
卷号
79
期号
2
页码范围
19558
出版商
Physicians Postgraduate Press, Inc.
简介
Objective: Autism and certain associated behaviors including self-injurious behaviors (SIB) and atypical pain reactivity have been hypothesized to result from excessive opioid activity. The objective of this study was to examine the relationships between SIB, pain reactivity, and β-endorphin levels in autism.
Methods: Study participants were recruited between 2007 and 2012 from day care centers and included 74 children and adolescents diagnosed with autism (according to DSM-IV-TR, ICD-10, and CFTMEA) and intellectual disability. Behavioral pain reactivity and SIB were assessed in 3 observational situations (parents at home, 2 caregivers at day care center, a nurse and child psychiatrist during blood drawing) using validated quantitative and qualitative scales. Plasma β-endorphin concentrations were measured in 57 participants using 2 different immunoassay methods.
Results: A high proportion of individuals …
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S Tordjman, GM Anderson, A Charrier, C Oriol… - The Journal of Clinical Psychiatry, 2018