作者
Farhang Mirzavandi, Mehdi Mollahosseini, Amin Salehi-Abargouei, Hassan Mozaffari-Khosravi
发表日期
2020/9/1
来源
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
卷号
14
期号
5
页码范围
1153-1161
出版商
Elsevier
简介
Background and aims
Previous studies have indicated that garlic consumption may be beneficial in improving inflammation. This systematic review and meta-analysis aimed to examine the effect of garlic supplementation on inflammatory biomarkers.
Methods
PubMed/Medline, Scopus and ISI web of science were searched up to February 2019. Random effects model was used to calculate the overall effects on C-reactive protein (CRP), Interleukin-6 (IL-6), and Tumor necrosis factor- α (TNF-α).
Results
17 randomized controlled trials (RCTs) were included in the meta-analyses. Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05). Sub-group analysis showed that aged garlic extract (AGE) was able to reduce CRP and TNF-α significantly (P < 0.05).
Conclusions
This meta-analysis showed that supplementation with garlic …
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F Mirzavandi, M Mollahosseini, A Salehi-Abargouei… - Diabetes & Metabolic Syndrome: Clinical Research & …, 2020