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Background:

Cardiorespiratory fitness as measured by peak oxygen consumption (VO 2peak) is a strong predictor of longevity and may be compromised by anticancer therapy, inactivity, and smoking. We compared VO 2peak among lymphoma survivors (LSs) with reference data from healthy sedentary subjects, after a 10.2-year (mean) follow-up post high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT). We further examined the association between VO 2peak and treatment, physical activity, smoking, pulmonary, and cardiac function.

Methods:

Lymphoma survivors treated with HDT-ASCT in Norway 1987–2008 were eligible. VO 2peak was assessed by cardiopulmonary exercise testing. Pulmonary function testing and echocardiography were also conducted. Data on treatment, physical activity, and smoking were collected from hospital records and questionnaires. VO 2peak was compared …