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With the imposition of the Movement Control Order (MCO) or lockdown due to the coronavirus disease 2019 (COVID-19) pandemic, there are drastic changes in the movement and activity among Malaysians: increased psychological distress due to perception of COVID-19 as a health threat, increased time spent with families, and decreased time away from home could either intensify relationship problems or draw families closer to each other. This study aimed to examine the perceived psychological distress and relationship quality among couples before and during MCO in Malaysia and factors predictive of participants’ well-being. The Depression Anxiety Stress Scale-21, Perceived Relationship Quality Component Inventory, and the Warwick–Edinburgh Mental Well-being Scale were disseminated through the snowball sampling technique. The study found that the participants (N= 124) perceived significantly …