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Cyclooxygenases (COX) are key enzymes in the conversion of arachidonic acid to prostaglandins. Several studies have shown a relation between angiogenesis and COX‐2 expression. Elevated expression of cyclooxygenase‐2 (COX‐2), however, has not been reported in multiple myeloma (MM) in the literature. The aim of this study is to investigate COX‐2 expression in MM as well as its correlation with prognostic factors and estimated survival rates. Immunohistochemical staining of the paraffin‐embedded bone marrow biopsy tissues (n = 51) was performed using isoform‐specific COX‐2 polyclonal antisera (Santa Cruz Biotechnology, Santa Cruz, CA). Results were correlated with recognized clinical parameters, which were retrospectively obtained from patients' files. There were 15, 19, and 17 bone marrow biopsy specimens with negative, weak–moderate, and strong COX‐2 immunostaining, respectively …