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Liver dysfunction is sometimes observed in patients with coronavirus disease 2019 (COVID‐19), but most studies are from China, and the frequency in other countries is unclear. In addition, previous studies suggested several mechanisms of liver damage, but precise or additional mechanisms are not clearly elucidated. Therefore, we examined COVID‐19 patients to explore the proportion of patients with liver dysfunction and also the factors associated with liver dysfunction.

We retrospectively examined 60 COVID‐19 patients hospitalized at the Hospital affiliated with The Institute of Medical Science, The University of Tokyo (Tokyo, Japan). Patients who presented ≥40 U/L alanine aminotransferase (ALT) levels at least once during their hospitalization were defined as high‐ALT patients, and the others as normal‐ALT patients. The worst values of physical and laboratory findings during hospitalization …