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Aortic stiffening and aortic calcification are risk factors for cardiovascular events in hemodialysis (HD) patients, and these 2 risk factors are interrelated. Sevelamer decreases aortic calcification but its effect on aortic stiffness has not been investigated previously. Thirteen HD patients commencing sevelamer treatment and 13 matched controls were followed for 11 months. Aortic pulse wave velocity (PWV), augmentation index (AIx), and levels of inhibitors of vascular calcification (fetuin‐A, matrix‐GLA‐protein, osteoprotegerin/RANKL) were measured at baseline and at the end of follow‐up, and the differences between the groups were compared. Determinants of the changes in PWV during follow‐up were assessed by multivariate linear regression. At baseline, PWV was 9.93 (2.10) m/s in sevelamer‐treated patients and 9.20 (2.84) m/s in control patients (p=0.464). By the end of follow‐up, PWV decreased by 0.83 …