作者
Victoria Nisenblat, David J Sharkey, Zhao Wang, Susan F Evans, Martin Healey, E Maria C Ohlsson Teague, Cristin G Print, Sarah A Robertson, M Louise Hull
发表日期
2019/6
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
104
期号
6
页码范围
1999-2022
出版商
Endocrine Society
简介
Context
Despite extensive searches for novel noninvasive diagnostics, laparoscopy remains the reference test for endometriosis. Circulating miRNAs are purported endometriosis biomarkers; however, the miRNA species and their diagnostic accuracy differ between studies and have not been validated in independent cohorts.
Objective
Identify endometriosis-specific plasma miRNAs and determine their diagnostic test accuracy.
Setting
Two university-based, public hospitals and a private gynecology practice in Australia.
Design and Participants
Four phases: (i) Explorative phase. Plasma miRNA menstrual cycle fluctuations were evaluated in women with endometriosis and asymptomatic controls (n = 16). (ii) Biomarker discovery. Endometriosis-specific plasma miRNAs were identified in (a) women with endometriosis and asymptomatic …
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V Nisenblat, DJ Sharkey, Z Wang, SF Evans, M Healey… - The Journal of Clinical Endocrinology & Metabolism, 2019