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Background: Blood pressure (BP) is main-tained within normal limits by the interplay of various mechanisms including the action of Cortisol and aldosterone. However, these hormones when exogenously administered are not under the regulatory feedback mechanisms that maintain BP homeostasis. Treatment of congenital adrenal hyperplasia (CAH) requires glucocorticoid replacement (with or without additional mineralocorticoid) at supra-physiological doses to normalize the pituitary adrenocortical axis.

Hypothesis: Long-term use of glucocorticoids at supra-physiological doses may result in high BP.

Objective: To document any changes in BP in patients with CAH following long-term conventional glucocorticoid replacement therapy.

Patients and Methods: 24-hour ambulatory BP