作者
Ana-Clara Bobadilla, Constanza Garcia-Keller, Jasper A Heinsbroek, Michael D Scofield, Victoria Chareunsouk, Cara Monforton, Peter W Kalivas
发表日期
2017/11
期刊
Neuropsychopharmacology
卷号
42
期号
12
页码范围
2377-2386
出版商
Nature Publishing Group
简介
Many studies support a perspective that addictive drugs usurp brain circuits used by natural rewards, especially for the dopamine-dependent reinforcing qualities of both drugs and natural rewards. Reinstated drug seeking in animal models of relapse relies on glutamate spillover from cortical terminals synapsing in the nucleus accumbens core (NAcore) to stimulate metabotropic glutamate receptor5 (mGluR5) on neuronal nitric oxide synthase (nNOS) interneurons. Contrasting the release of dopamine that is shared by sucrose and drugs of abuse, reinstated sucrose seeking does not induce glutamate spillover. We hypothesized that pharmacologically promoting glutamate spillover in the NAcore would mimic cocaine-induced adaptations and potentiate cued reinstatement of sucrose seeking. Inducing glutamate spillover by blocking astroglial glutamate transporters (GLT-1) had no effect on reinstated sucrose …
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AC Bobadilla, C Garcia-Keller, JA Heinsbroek… - Neuropsychopharmacology, 2017