查看文章

Antioxidant vitamins have attracted considerable attention in previous studies of esophageal squamous‐cell carcinoma, but dietary studies of adenocarcinoma of the esophagus and gastric cardia remain sparse. Treating these tumors as distinct diseases, we studied intakes of vitamin C, beta‐carotene and alpha‐tocopherol in a nationwide population‐based case‐control study in Sweden, with 185, 165, and 258 cases of esophageal adenocarcinoma, esophageal squamous‐cell carcinoma, and gastric cardia adenocarcinoma, respectively, and 815 controls. Subjects with a high parallel intake of vitamin C, beta‐carotene, and alpha‐tocopherol showed a 40–50% decreased risk of both histological types of esophageal cancer compared with subjects with a low parallel intake. Antioxidant intake was not associated with the risk of gastric cardia adenocarcinoma. Separately, vitamin C and beta‐carotene reduced the …